Simulink build a loop and define intial conditions
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Jon on 16 Nov 2021
Edited: Jon on 16 Nov 2021
In general you should be able to run your simulation iteratively by starting the simulation programatically using the MATLAB sim function (if you're not already familiar with the sim function, type doc sim on your command line to read the documentation)
So you would make a loop, something like this
for k = 1:numIterations
simout = sim('myModel',...)
% now do something with the output variables ...
% for example assign base workspace variable that are used as inputs in
% next loop
a = simout....
b = simout. ...
You may want to look at the documentation for the fast restart option, to avoid compiling the Simulink model with each iteration https://www.mathworks.com/help/simulink/ug/fast-restart-workflow.html
Exactly how you assign the outputs to the inputs depends upon what kind of values you are changing. However if they are values of constant blocks or mask parameter values that are assigned to base workspace variables it is as simple as reassigning these base workspace values (as I indicated in the example above)