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Hi! I'm new to pk modeling and Matlab. Can someone guide me through how to conduct population pk modeling based on pk parameters from non-human primate studies? Much thanks!!!!
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rugby, track, cricket, racing, etc.
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3712 votes
You reached this milestone by providing valuable contribution to the community since you started answering questions in Since September 2018.
You provided 3984 answers and received 1142 votes. You are ranked #24 in the community. Thank you for your contribution to the community and please keep up the good track record!
MATLAB Central Team
The MATLAB AI Chat Playground is now open to the whole community! Answer questions, write first draft MATLAB code, and generate examples of common functions with natural language.
The playground features a chat panel next to a lightweight MATLAB code editor. Use the chat panel to enter natural language prompts to return explanations and code. You can keep chatting with the AI to refine the results or make changes to the output.
Give it a try, provide feedback on the output, and check back often as we make improvements to the model and overall experience.
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The title is resonably non-descript, but I can explain it easily:
Say I have an initial Emax model:
v = emax1*[G]^n1/(ec501^n1+[G]^n1)
And I want to place v inside of a second Emax model:
y = emax2*v^n2/(ex502^n2+v^n2)
Currently, I have the full function of v inside y, twice, it's very long and whilst I only need to get it correct once, for readability in the future I'd rather have it in form #2. I've played around with non-constant parameters but I need the steady state to be v, not the rate rule, and I haven't worked out how to make a parameter shift to a form like v, as an observation might.
Are there any recommended solutions or do I simply need to keep with having v fully expressed in y?
Thank you,
Dan
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Hi All,
I'm currently attempting to implement a Hodgkin-Huxley-type model of membrane potential, ideally I would like a species that represents the membrane potential as its own distinct entity, so as the reference elsewhere. I've currently established a molarity-based work around but it would be great if I could set the units for the species as millivolt, but that throws an error.
Is there an established way to do this? I imagine I'm not the first person to be trying to model a voltage-gated ion channel!
Thank you for your help.
Here's a MATLAB class I wrote that leverages the MATLAB Central Interface for MATLAB toolbox, which in turn uses the publicy available Community API. Using this class, I've created a few Favorites that show me what's going on in MATLAB Central - without having to leave MATLAB 🙂
The class has a few convenient queries:
- Results for the last 7 days
- Results for the last 30 days
- Results for the current month
- Results for today
And supporting a bunch of different content scopes:
- All MATLAB Central
- MATLAB Answers
- Blogs
- Cody
- Contests
- File Exchange
- Exclude Answers content
The results are displayed in the command window (which worked best for me) and link to each post. Here's what that looks like for this command
>> CommunityFeed.thisMonth("app designer", CommunityFeed.Scope.ExcludeAnswers)
Let me know if you find this class useful and feel free to suggest changes.
Hello,
I've looked around and I haven't found anything obvious about this, but is it possible to link to species/reactions, graphically, in a non-mass transfer sense? I have areas in my model where it would conceptually make sense to be able to see that species or reactions are linked, but if I link them in the standard way it demands that it be involved in the stoichiometry.
Perhaps some kind of dotted line, or similar?
Thank you, best regards,
Dan
New Cheat Sheet Alert!
Level up your data organization and access skills in MATLAB with our latest cheat sheet! Download the full cheat sheet on MATLAB GitHub for Students here.
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2097 votes
Adam and Heather will be discussing new features in R2023b and answering your questions in a few hours - visit the link below to check out the preview and sign up for notification.
Hello all,
I've been trying to shift my workflow more towards simbiology, it has a lot of very interesting features and it makes sense to try and do everything in one place if it works well..! Part of my hesitancy into this was some bad experiences handling units in the past, though this was almost certainly all out of my own ignorance, relatedly:
Getting onto my question.
In this model I have a species traveling around the body via blow flow, think a basic PBPK model. My species are picomolarities, if everything is already in concentrations, why is it necessary to initially divide by the compartment volume? i.e. 1/Pancreas below.
If my model dealt in molar quantities this would make a lot of sense, the division would represent the transition to concentrations. This, however, now necessitates my parameters be in units of liter/minute, which is actually correct, but I'd like clarification on why it's correct, ha!
Perhaps this is more of a modelling question than a simbiology question, but if there are answers I'd love to hear them. Thanks!
Adam Danz just launched a new blog about MATLAB Graphics and App Building.
As you know, He has been a prolific contributor to MATLAB Answers and one of his answers recently won the Editor's Choice Award.
If there are any topics or questions you are interested in, please share with Adam, and I am sure he will get those into his blog.
Calling all students! New to MATLAB or need helpful resources? Check out our MATLAB GitHub for Students repository! Find MATLAB examples, videos, cheat sheets, and more!
Visit the repository here: MATLAB GitHub for Students
Imagine x is a large vector and you want the smallest 10 elements. How might you do it?
4 months ago, the new API was published to access content on the MATLAB Central community. I shared my MATLAB code to access the API at that time, but the team just released the official SDK.
MATLAB toolbox on File Exchange: https://www.mathworks.com/matlabcentral/fileexchange/135567-matlab-central-interface-for-matlab
Houman and Rameez will talk about how you can model wireless networks (5G, WLAN, Bluetooth, 802.11ax WLAN mesh, etc.) in MATLAB in the upcoming livestream. They will start with the basics such as nodes, links, topology and metrics. Then they will introduce a new free add-on library that lets you model such networks, and show you how to use it.
- Date: Thu, Oct 5, 2023
- Time: 11 am EDT (or your local time)
Bookmark this link:
Congratulations, @Adam Danz for winning the Editor's Pick badge awarded for MATLAB Answers, in recognition of your awesome solution in overlapping images in grid layout.
Thank you for going to great lengths to help a user in this thread by suggesting alternative approach to representing stack of playing cards in MATLAB, highlighting very interesting features like hggroup.
This badge recognizes awesome answers people contribute and yours was picked for providing a very detailed and helpful answer.
Thank you so much for setting a high standard for MATLAB Answers and for your ongoing contribution to the community.
MATLAB Central Team
