I am currently and actively working with the insulindemo included in the toolbox simBiology.
for the object named Type 2 diabetic, I ran a first simulation using the default values.
Then I wanted to change the values of the parameters m5 and m6, the modification of these two values shold be reflected in the value of the initial assignment
[Basal Ins Secr] = (m6-[Basal Hepatic Extraction])/m5
using the defautl values m6 = 0.8118 and m5 = 0.0526 I get a value for the [Basal Ins Secr] of 4.0266
However, if I use m6 = 0.6471 and m5 = 0.0304 ([Basal Ins Secr] = 1.5493) and I run the simulation the value of [Basal Ins Secr] remains the same as for the defaul values.
My question is whether the values of the parameters are changeable or not.
Thank yo very much in advance, I'm looking forward to hear from you.
I wish you a very good day.