Accessing PK library models from code

Hello,

Is there a way to access models from the PK library from code? I see there's a PKModelDesign class, but I'm wondering if there's a way for me to access one of the pre-built PK models from code. I'm using R2020b.

Thank you,

Abed

Answer 1

[Rick Paxson]

Hello,

Yes you can use PKModelDesign to construct simple PK models from the command line (i.e. in code).

I'll refer you to the documentation for the details and all the options available but here is a simple example.

pkm = PKModelDesign;
pkm.addCompartment('Central', 'DosingType', 'Bolus', ...
                   'EliminationType', 'linear-clearance', ...
                   'HasResponseVariable', true);
modelObj = pkm.construct;

This will make a one compartment model with linear elimination and parameterized with clearance (i.e. a clearance parameter is built).

Hope this answers your question.

[Abed Alnaif]

Hi Pax, Thanks. One question: my understanding is that, if I used models from the built in library, SimBiology runs the model using the analytical solution, rather than running it numerically. Is this also true if I use PKModelDesign, that the model runs using the analytical solution? I was just curious. Thanks, Abed