Differentiating algebraic equation fractions

Hi guys, have a test coming up and i will be able to use matlab.
How do i differentiate algebraic equations such as fractions, in real life we will use the quotient rule, but how do i do it using matlab?
Ex: d/dx ((-x^2-x)/(x+2)*(x+3))
What will i enter into matlab for it to be differentiated?

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R2018b

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