Transit Compartments with Simbiology

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Andy
Andy on 30 Mar 2018
Edited: Andy on 2 Apr 2018
Do you have a good example in Simbiology for me modify the built-in PK models that would create 3 transit compartments prior to absorption.
Basically, I would like to create a one-compartmental PK model with 3 transit compartments and then the standard Ka parameter with first order dosing. I then want to do the same for a 2-compartmental PK model with 3 transit compartments prior to absorption.
Example 1: V, CL, Ka, MTT and Example 2: Vc, CL, Q, Vp, MTT
I attempted to use the gPKPDSim package and thought to use the standard Simbiology interface instead.
Andy

Accepted Answer

Arthur Goldsipe
Arthur Goldsipe on 30 Mar 2018
Have you seen the documentation example Estimate Pharmacokinetic Parameters Using SimBiology Desktop? It walks you through selecting a PK model from the built-in library within SimBiology. You should see that there are several options for 3-compartment models. See if any of those are a good starting point for you.

More Answers (2)

Andy
Andy on 30 Mar 2018
Edited: Andy on 30 Mar 2018
Hi Arthur, I opened the 3-compartment PK model and will modify the contents.
I will take good look at this and get back to you.
Thanks, Andy

Andy
Andy on 2 Apr 2018
Edited: Andy on 2 Apr 2018
Arthur, I saw the concept from the 3-compartment model and was able to create the 3 transit compartments by modifying a two-compartment model in approximately 1-hour. So, thank God, it worked.
Thanks.

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