Transit Compartments with Simbiology
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Do you have a good example in Simbiology for me modify the built-in PK models that would create 3 transit compartments prior to absorption.
Basically, I would like to create a one-compartmental PK model with 3 transit compartments and then the standard Ka parameter with first order dosing. I then want to do the same for a 2-compartmental PK model with 3 transit compartments prior to absorption.
Example 1: V, CL, Ka, MTT and Example 2: Vc, CL, Q, Vp, MTT
I attempted to use the gPKPDSim package and thought to use the standard Simbiology interface instead.
Arthur Goldsipe on 30 Mar 2018
Have you seen the documentation example Estimate Pharmacokinetic Parameters Using SimBiology Desktop? It walks you through selecting a PK model from the built-in library within SimBiology. You should see that there are several options for 3-compartment models. See if any of those are a good starting point for you.
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