How can I estimate PD parameters for two - compartment model?
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BLESSING AKAH
on 12 Apr 2022
Commented: BLESSING AKAH
on 15 Apr 2022
I have a two compartment model with two types of dosing: PK dose and PD dose (scheduled).
I have mapped the data correctly, but my estimate is far off from the reference paper I was using as a prototype. I know thet fit program is for parameter estimate, however I dont know how to assign the baseline dose. Note, the model has no variant.
I do not know what excatly I am doing wrong, and i really do need help with this; been stuck with it for more than a week.
2 Comments
Arthur Goldsipe
on 12 Apr 2022
It's very difficult to figure out the problem without more details. Can you share the project you created and the results you are trying to reproduce?
Accepted Answer
Arthur Goldsipe
on 12 Apr 2022
I looked at the project you attached in the comments. I didn't see any obvious problems. Your parameter estimates are within a factor of 2 of the ones you're trying to match. Do you have any reason to believe you should be able to reproduce the reported values more closely? If so, you will likely need to get more details from the author to make sure you are reproducing their model and their estimation methods. In fact, before you try to reproduce their estimation results, I recommend making sure you can reproduce their simulation results for a specific condition. For example, do the authors provide simulation results of tumor weight at the estimated parameter values? If so, can you simulate the same conditions and compare your simulation results? If those don't agree, then you may have a problem with your model. If those do agree, then I recommend double-checking that you're using the correct data and the same fitting approach (for example, the same error model).
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BLESSING AKAH
on 13 Apr 2022
8 Comments
Arthur Goldsipe
on 15 Apr 2022
Oh, glad I attached the project so that you could catch my mistake with the error model.
I'm sorry, but I don't have time to read the paper closely enough to figure out whether there's some missing data or dosing information. I suggest contacting the authors, since they would know best. I see contact information listed at the end of the paper.
If you figure out what's going on, I'd love to hear more about it. Feel free to contact me directly.
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