How can I estimate PD parameters for two - compartment model?
1 view (last 30 days)
BLESSING AKAH on 12 Apr 2022
I have a two compartment model with two types of dosing: PK dose and PD dose (scheduled).
I have mapped the data correctly, but my estimate is far off from the reference paper I was using as a prototype. I know thet fit program is for parameter estimate, however I dont know how to assign the baseline dose. Note, the model has no variant.
I do not know what excatly I am doing wrong, and i really do need help with this; been stuck with it for more than a week.
Arthur Goldsipe on 12 Apr 2022
I looked at the project you attached in the comments. I didn't see any obvious problems. Your parameter estimates are within a factor of 2 of the ones you're trying to match. Do you have any reason to believe you should be able to reproduce the reported values more closely? If so, you will likely need to get more details from the author to make sure you are reproducing their model and their estimation methods. In fact, before you try to reproduce their estimation results, I recommend making sure you can reproduce their simulation results for a specific condition. For example, do the authors provide simulation results of tumor weight at the estimated parameter values? If so, can you simulate the same conditions and compare your simulation results? If those don't agree, then you may have a problem with your model. If those do agree, then I recommend double-checking that you're using the correct data and the same fitting approach (for example, the same error model).