Simulation of tissue drug concentration profile with Kp values

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I'm trying to develop the compartment model to simulate a lung concentration time profile of unchanged and metabolized drugs with tissue Kp value in simbiology app. This is because these drugs have very high lung Kp values (i.e. 100). I tried that lung concentration of unchanged drugs equals to the product of peripheral concentration and the lung Kp with repeated assginment, but I was not able to cope with this equation and the differential equation for the metabolism of unchanged drugs to metabolites in lung. How can I incorporate Kp values for the simulation of tissue concentration?

Accepted Answer

Arthur Goldsipe
Arthur Goldsipe on 14 Oct 2021
If you are looking for an example of how to incorporate tissue partition coefficients into a PBPK model, then perhaps you can use the following SimBiology model as an example: Generic SimBiology PBPK model
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和孝 関口
和孝 関口 on 17 Oct 2021
Thank you so much, Arthur. I was able to take a look PBPK model and it was helpful for me.

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