random
Simulate SimBiology model, adding variations by sampling error model
Syntax
Description
[
returns simulation results ynew
,parameterEstimates
]
= random(resultsObj
)ynew
with added noise using the
error model information specified by the
resultsObj.ErrorModelInfo
property and estimated parameter
values parameterEstimates
.
[
uses the specified ynew
,parameterEstimates
]
= random(resultsObj
,data
,dosing
)data
and dosing
information.
[
also applies the specified variants to each simulation.ynew
,parameterEstimates
]=
random(resultsObj
,data
,dosing
,'Variants',v
)
Note
The noise is only added to states that are responses which are the states
included in the responseMap
input argument when you
called sbiofit
or the ResponseMap
property of fitproblem
. If there is a separate error model
for each response, the noise is added to each response separately using the
corresponding error model.
Examples
Add Noise to Simulation Results of a Fitted SimBiology Model
This example uses the yeast heterotrimeric G protein model and experimental data reported by [1]. For more details about the model, see the Background section in Parameter Scanning, Parameter Estimation, and Sensitivity Analysis in the Yeast Heterotrimeric G Protein Cycle.
Load the G protein model.
sbioloadproject gprotein
Enter the experimental data containing the time course for the fraction of active G protein, as reported in the reference paper [1].
time = [0 10 30 60 110 210 300 450 600]'; GaFracExpt = [0 0.35 0.4 0.36 0.39 0.33 0.24 0.17 0.2]';
Create a groupedData
object based on the experimental
data.
tbl = table(time,GaFracExpt); grpData = groupedData(tbl);
Map the appropriate model component to the experimental data. In other
words, indicate which species in the model corresponds to which response
variable in the data. In this example, map the model parameter
GaFrac
to the experimental data variable
GaFracExpt
from grpData
.
responseMap = 'GaFrac = GaFracExpt';
Use an estimatedInfo
object to define the model
parameter kGd
as a parameter to be estimated.
estimatedParam = estimatedInfo('kGd');
Perform the parameter estimation. Use the namevalue pair argument
'ErrorModel'
to specify the error model that adds
error to simulation data.
fitResult = sbiofit(m1,grpData,responseMap,estimatedParam,'ErrorModel','proportional');
View the estimated parameter value of kGd
.
fitResult.ParameterEstimates
ans = Name Estimate StandardError _____ ________ _____________ 'kGd' 0.11 0.00064116
Use the random
method to retrieve the simulation data
with added noise using the proportional error model which was specified by
sbiofit
. Note that the noise is added only to the
response state, that is the GaFrac
parameter.
[ynew,paramEstim] = random(fitResult);
Select the simulation data for the GaFrac
parameter.
GaFracNew = select(ynew,{'Name','GaFrac'});
Plot the simulation results.
plot(GaFracNew.Time,GaFracNew.Data)
hold on
Plot the experimental data to compare it with the simulated data.
plot(time,GaFracExpt,'Color','k','Marker','o') legend('GaFracNew','GaFracExpt')
Input Arguments
resultsObj
— Estimation results
OptimResults
object  NLINResults
object
Estimation results, specified as an OptimResults object
or
NLINResults object
, which
contains estimation results returned by sbiofit
. It must be a
scalar object.
data
— Grouped data or output times
groupedData
object  vector  cell array of vectors
Grouped data or output times, specified as a groupedData
object
, vector, or cell array of vectors of output
times.
If it is a vector of time points, random
simulates
the model with new time points using the parameter estimates from the
results object resultsObj
.
If it is a cell array of vectors of time points,
random
simulates the model n
times using the output times from each time vector, where
n is the length of data
.
If it is a groupedData
object, it must have an
independent variable such as Time. It must also have a group variable if the
training data used for fitting has such variable. You can use a
groupedData
object to query different combinations of
categories if the resultsObj
contains parameter
estimates for each category. random
simulates the model
for each group with the specified categories. For instance, suppose you have
a set of parameter estimates for sex category (males versus females), and
age category (young versus old) in your training data. You can use
random
to simulate the responses of an old male (or
any other combination) although such patient may not exist in the training
data.
If the resultsObj
is from estimating
categoryspecific parameters, data
must be a
groupedData
object.
Note
If UnitConversion
is turned on for the underlying
SimBiology model that was used for fitting and data
is a groupedData
object, data
must specify valid variable units via
data.Properties.VariableUnits
property. If it is
a numeric vector or cell array of vectors of time points,
random
uses the model’s
TimeUnits
.
dosing
— Dosing information
[]
 {}
 2D matrix of dose objects  cell vector of dose objects
Dosing information, specified as empty []
or {}
, 2D matrix or cell vector of SimBiology dose objects (ScheduleDose object
or RepeatDose object
).
If dosing
is empty, no doses are applied during simulation, even if the model has active doses.
For a matrix of dose objects, it must have a single row or one row per group in the input data. If it has a single row, the same doses are applied to all groups during simulation. If it has multiple rows, each row is applied to a separate group, in the same order as the groups appear in the input data. Multiple columns are allowed so that you can apply multiple dose objects to each group.
For a cell vector of doses, it must have one element or one element per group in the input
data. Each element must be []
or a vector of doses. Each element of the
cell is applied to a separate group, in the same order as the groups appear in the input
data.
In addition to manually constructing dose objects using sbiodose
, if the input groupedData
object has dosing
information, you can use the createDoses
method to construct
doses.
Dose objects of the dosing
input must be consistent with the original dosing data used with sbiofit
. The objects must have the same values for dose properties (such as TargetName
) or must be parameterized in the same way as the original dosing data. For instance, suppose that the original dosing matrix has two columns of doses, where the doses in the first column target species x and those in the second column target species y. Then dosing
must have doses in the first column targeting species x and those in the second column targeting species y. A parameterized dose example is as follows. Suppose that the Amount
property of a dose used in the original sbiofit
call is parameterized to a modelscoped parameter 'A'
. All doses for the corresponding group (column) in the dosing
matrix input must have the Amount
property parameterized to 'A'
.
The number of rows in the dosing
matrix or number of elements in the dosing
cell vector and the number of groups or output time vectors in data
determine the total number of simulation results in the output ynew
. For details, see the table in the ynew
argument description.
Note
If UnitConversion
is turned on for the underlying SimBiology^{®} model that was used for fitting, dosing
must specify valid amount and time units.
v
— Variants to apply
[]
 {}
 2D matrix of variants  cell vector of variants
Variants to apply, specified as an empty array ([]
, {}
), 2D matrix or cell vector of variant objects.
If you do not specify this argument, the function has the following behavior depending on whether the second input argument (data
) is specified also or not.
If
data
is not specified, the function applies the groupspecific variants from the original call tosbiofit
.If
data
is a vector or cell array of output times, the function does not apply the groupspecific variants.If
data
is agroupedData
object, the function applies variants only to groups whose group identifier matches a group identifier in the original training data that was used in the call tosbiofit
.
Note
The baseline variants that were specified by the variants positional input argument in the original call to
sbiofit
are always applied to the model, and they are applied before any groupspecific variants.If there are no baseline variants, that is, you did not specify the
variants
input when callingsbiofit
, therandom
function still applies the model active variants if there are any.
If the argument value is []
or {}
, the function applies no groupspecific variants.
If it is a matrix of variants, it must have either one row or one row per group. Each row is
applied to a separate group, in the same order as the groups appear in
data
or dosing
. If it has a single row, the
same variants are applied to all groups during simulation. If there are multiple columns,
the variants are applied in order from the first column to the last.
If it is a cell vector of variant objects, the number of cells must be one or must match
the number of groups in the input data. Each element must be []
or a
vector of variants. If there is a single cell containing a vector of variants, they are
applied to all simulations. If there are multiple cells, the variants in the
ith cell are applied to the simulation of the ith
group.
The function defines the number of groups by examining the data
, and
dosing
input arguments.
data
can have1
or N groups.If
data
anddosing
arguments are not specified, then the default data and dosing are determined as follows:For unpooled fits, they are the data and dosing for the single group associated with that fit results.
For all other fits, they are the entire set of data and dosing associated with the call to
sbiofit
.
Output Arguments
ynew
— Simulation results with noise
vector of SimData
objects
Simulation results, returned as a vector of SimData
objects. The states reported in ynew
are the states that were included in the responseMap
input argument of sbiofit
as well as any other states listed in the StatesToLog
property of the runtime options (RuntimeOptions
) of the SimBiology model.
The total number of simulation results in ynew
depends on the number of groups or output time vectors in data
and the number of rows in the dosing
matrix.
Number of groups or output time vectors in data  Number of rows in the dosing matrix  Simulation results 


 The total number of No doses are applied during simulation. 

 The total number of The given row of doses is applied during the simulation. 
 N  The total number of Each row of 
N 
 The total number of No doses are applied during simulation. 
N 
 The total number of The same row of doses is applied to each simulation. 
N  N  The total number of Each row of 
M  N  The function throws an error when M ≠ N. 
parameterEstimates
— Estimated parameter values
table
Estimated parameter values, returned as a table. This is identical to
resultsObj.ParameterEstimates
property.
References
[1] Yi, TM., Kitano, H., and Simon, M. (2003). A quantitative characterization of the yeast heterotrimeric G protein cycle. PNAS. 100, 10764–10769.
See Also
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