SimBiology Apps

Interactive apps to facilitate building, simulating, and analyzing dynamic systems

SimBiology provides a set of integrated apps that are designed to facilitate building, simulating, and analyzing models of dynamic systems such as quantitative systems pharmacology (QSP), pharmacokinetic/pharmacodynamic (PK/PD) and systems biology models.

  • The SimBiology app lets you build dynamic models interactively using various modeling elements. For instance, you can model a variety of biological systems such as signaling pathways, metabolic networks, PBPK, QSP, and PK/PD models. It also lets you model biological variability and different dosing regimens to investigate various experimental conditions and dosing strategies.

  • The SimBiology Model Analyzer app lets you perform analyses on models of dynamic systems. You can simulate the dynamic behavior of a model using various solvers and estimate model parameters. To investigate system dynamics and guide experimentation, you can perform sensitivity analysis and parameter sweeps.

Apps

SimBiologyBuild PK/PD and mechanistic systems biology models interactively
SimBiology Model AnalyzerAnalyze PK/PD and mechanistic systems biology models

Topics

Build Models

Create Model of Receptor-Ligand Kinetics

This example shows how to create and simulate a simple model of receptor-ligand kinetics using the SimBiology app and SimBiology Model Analyzer app.

Model Views in SimBiology App

The SimBiology app provides three different views of a model: the Diagram view, Table view, and Equations view.

Copy SimBiology Blocks

Copy and paste SimBiology blocks while building models in the Diagram.

Keyboard Shortcuts for SimBiology App

The SimBiology app provides keyboard shortcuts for various modeling actions.

Analyze Models and Data

Calculate NCA Parameters and Fit Model to PK/PD Data Using SimBiology Model Analyzer App

Perform noncompartmental analysis and calibrate model parameters by fitting to experimental PKPD data using nonlinear regression.

Find Important Parameters with Sensitivity Analysis Using SimBiology Model Analyzer App

Perform sensitivity analysis to find important model parameters.

Model Biological Variability with Virtual Patients Using SimBiology Model Analyzer App

Generate sample values for model parameters to represent virtual patients and simulate to explore model variability.

Scan Dosing Regimens Using SimBiology Model Analyzer App

Explore multiple dosing amounts that meets the efficacy and toxicity thresholds.