SimBiology Desktop

User interface to facilitate building, simulating, and analyzing dynamic systems

The SimBiology® desktop is a user interface with a set of integrated tools that are designed to facilitate building, simulating, and analyzing models of dynamic systems such as pharmacokinetic/pharmacodynamic (PK/PD) and mechanistic systems biology models. It lets you build models interactively and perform model analyses such as simulation, sensitivity calculation, and parameter estimation. You can also build standalone applications for model distribution and simulation.


simbiologyOpen SimBiology desktop for modeling and simulation


Desktop Overview

General Workflow

You can build, simulate, and analyze models of dynamic systems using a set of integrated tools in the SimBiology desktop.

SimBiology Desktop Navigation

The SimBiology desktop displays models, task results, and external data in the workspace area and the task information in the task editor.

SimBiology Desktop Help and Tools

The SimBiology desktop provides various tools for model building and error checking, and context-sensitive help for more information.

Setting Preferences

You can change the desktop settings that apply to all projects.


The SimBiology libraries are collections of built-in components that you can use to build and analyze models.

Keyboard Shortcuts for SimBiology Desktop

The SimBiology desktop provides keyboard shortcuts for various modeling actions.


Modeling Workflow

The SimBiology desktop lets you build dynamic models interactively using various modeling elements and checks for errors and warnings.

Model Views

The SimBiology desktop provides three different views of a model: the Diagram view, Table view, and Equations view.

Copying SimBiology Blocks

Copy and paste SimBiology blocks while building models in the Diagram.


Analysis Workflow

You can analyze models of dynamic systems using built-in analysis tools and create standalone applications for model distribution and simulation.

Task Editor

The Task Editor lets you configure task settings, run the tasks, and visualize live simulation results as a task is running.

Built-in Tasks

The SimBiology desktop provides several built-in tasks for model simulation and analyses.

Configuring Tasks

For each task, you can configure model-related settings, simulation-related settings, and task-specific settings.

Running Tasks

You can run tasks to analyze models of dynamic systems and explore them using various exploration tools.


External Data and Task Results

There are two types of data in the SimBiology desktop: external data that you can import from experiments and task results generated by each task after it finishes running.

Noncompartmental Analysis

NCA (noncompartmental analysis) lets you calculate pharmacokinetic parameters of a drug without requiring the assumption of a compartmental model.